TAMI-29. MULTIFACTORIAL UPREGULATION OF ID1 DRIVES DIPG INVASIVENESS AND IS THERAPEUTICALLY TARGETABLE

Diffuse intrinsic pontine gliomas (DIPGs) are lethal brain tumors with no effective therapies other than radiation. Inhibitor of DNA binding (ID) proteins, key regulators of lineage commitment during embryogenesis, are implicated in tumorigenesis in multiple human cancers. Prior work showed that rec...

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Veröffentlicht in:Neuro Oncol
Hauptverfasser: Nand Yadav, Viveka, Harris, Micah K, Stallard, Stefanie, Woo, Rinette, Siddaway, Robert, Qin, Tingting, Cummings, Jessica, Mullan, Brendan, Miklja, Zachary, Siada, Ruby, Ravindran, Ramya, Cao, Xuhong, Pasternak, Amy, Castro, Maria G, Lowenstein, Pedro, Mody, Rajen, Chinnaiyan, Arul, Hawkins, Cynthia, Desprez, Pierre, McAllister, Sean, Venneti, Sriram, Koschmann, Carl
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2020
Schlagworte:
Tumor Microenvironment/Angiogenesis/Metabolism/Invasion
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651395/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.917
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