DDRE-07. DIPG HARBOUR ALTERATIONS TARGETABLE BY MEK INHIBITORS, WITH ACQUIRED RESISTANCE MECHANISMS OVERCOME BY COMBINATORIAL INHIBITION

The survival of children with diffuse intrinsic pontine glioma (DIPG) remains dismal, with new treatments desperately needed. In the era of precision medicine, targeted therapies represent an exciting treatment opportunity, yet resistance can rapidly emerge, playing an important role in treatment fa...

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書目詳細資料
發表在:Neuro Oncol
Main Authors: Izquierdo, Elisa, Carvalho, Diana, Mackay, Alan, Temelso, Sara, Boult, Jessica K R, Molinari, Valeria, Stubbs, Mark, Grabovska, Yura, Yu, Lu, Choudhary, Jyoti, Depani, Sarita, o’Hare, Patricia, Robinson, Simon P, Hubank, Michael, Hargrave, Darren, Jones, Chris
格式: Artigo
語言:Inglês
出版: Oxford University Press 2020
主題:
Drug Discovery, Drug Resistance
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651291/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.252
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