DDRE-07. DIPG HARBOUR ALTERATIONS TARGETABLE BY MEK INHIBITORS, WITH ACQUIRED RESISTANCE MECHANISMS OVERCOME BY COMBINATORIAL INHIBITION

The survival of children with diffuse intrinsic pontine glioma (DIPG) remains dismal, with new treatments desperately needed. In the era of precision medicine, targeted therapies represent an exciting treatment opportunity, yet resistance can rapidly emerge, playing an important role in treatment fa...

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Bibliografski detalji
Izdano u:Neuro Oncol
Glavni autori: Izquierdo, Elisa, Carvalho, Diana, Mackay, Alan, Temelso, Sara, Boult, Jessica K R, Molinari, Valeria, Stubbs, Mark, Grabovska, Yura, Yu, Lu, Choudhary, Jyoti, Depani, Sarita, o’Hare, Patricia, Robinson, Simon P, Hubank, Michael, Hargrave, Darren, Jones, Chris
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2020
Teme:
Drug Discovery, Drug Resistance
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651291/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.252
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