DDRE-10. IMMUNE PROFILES ASSOCIATE WITH OUTCOMES IN HLA-A*02:01(+), H3.3K27M(+) PATIENTS WITH DIFFUSE MIDLINE GLIOMAS TREATED WITH H3.3K27M PEPTIDE VACCINE COMBINED WITH POLY-ICLC: A PNOC REPORT

BACKGROUND: Patients with diffuse midline gliomas (DMG), including diffuse intrinsic pontine glioma (DIPG), have dismal outcomes. We previously described the H3.3K27M mutation as a shared neoantigen in HLA-A*02.01(+) H3.3K27M(+) DMGs. Within the Pacific Pediatric Neuro-Oncology Consortium, we assess...

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Vydáno v:Neuro Oncol
Hlavní autoři: Mueller, Sabine, Taitt, Jared M, Villanueva-Meyer, Javier, Bonner, Erin R, Nejo, Takahide, Lulla, Rishi R, Goldman, Stewart, Banerjee, Anurhada, Chi, Susan, Whipple, Nicholas S, Crawford, John R, Gauvain, Karen, Nazemi, Kellie, Watchmaker, Payal, Almeida, Neil D, Okada, Kaori, Salazar, Andres, Gilbert, Ryan, Nazarian, Javad, Molinaro, Annette, Butterfield, Lisa H, Prados, Michael, Okada, Hideho
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Drug Discovery, Drug Resistance
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651114/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.255
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