DDRE-10. IMMUNE PROFILES ASSOCIATE WITH OUTCOMES IN HLA-A*02:01(+), H3.3K27M(+) PATIENTS WITH DIFFUSE MIDLINE GLIOMAS TREATED WITH H3.3K27M PEPTIDE VACCINE COMBINED WITH POLY-ICLC: A PNOC REPORT

BACKGROUND: Patients with diffuse midline gliomas (DMG), including diffuse intrinsic pontine glioma (DIPG), have dismal outcomes. We previously described the H3.3K27M mutation as a shared neoantigen in HLA-A*02.01(+) H3.3K27M(+) DMGs. Within the Pacific Pediatric Neuro-Oncology Consortium, we assess...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Mueller, Sabine, Taitt, Jared M, Villanueva-Meyer, Javier, Bonner, Erin R, Nejo, Takahide, Lulla, Rishi R, Goldman, Stewart, Banerjee, Anurhada, Chi, Susan, Whipple, Nicholas S, Crawford, John R, Gauvain, Karen, Nazemi, Kellie, Watchmaker, Payal, Almeida, Neil D, Okada, Kaori, Salazar, Andres, Gilbert, Ryan, Nazarian, Javad, Molinaro, Annette, Butterfield, Lisa H, Prados, Michael, Okada, Hideho
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Drug Discovery, Drug Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651114/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.255
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