IMMU-23. A NOVEL MASS CYTOMETRY-BASED MULTI-PARAMETER CHARACTERIZATION OF NEOANTIGEN-REACTIVE CD8+ T-CELLS IN PATIENTS PARTICIPATING IN PNOC007 H3.3K27M PEPTIDE VACCINE CLINICAL TRIAL

BACKGROUND: We have identified an HLA-A*02:01-restricted neoantigen epitope encompassing the H3.3K27M mutation and implemented a multi-center clinical trial of the peptide vaccine through the Pacific Pediatric Neuro-Oncology Consortium (PNOC007) for patients with diffuse midline glioma (DMG), includ...

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Опубликовано в: :Neuro Oncol
Главные авторы: Taitt, Jared, Nejo, Takahide, Watchmaker, Payal, Almeida, Neil, Okada, Kaori, Shahin, Maryam, Gilbert, Ryan, Molinaro, Annette, Prados, Michael, Mueller, Sabine, Okada, Hideho
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2020
Предметы:
Immunotherapy
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715730/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.379
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