EXTH-05. NON-CYTOTOXIC RADIATION ENHANCES DELIVERY OF ANTISENSE OLIGONUCLEOTIDES AND IMPROVES CHEMO-RADIATION EFFICACY IN BRAIN TUMOR XENOGRAFTS

Overexpression of O(6)-methylguanine DNA methyltransferase (MGMT) contributes to brain tumor chemo-resistance. Previously we found that non-cytotoxic radiation improved anti-MGMT Morpholino Oligonucleotides (AMONs) delivery to reduce MGMT levels in subcutaneous tumor xenografts. Here we evaluated if...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Wu, Jeffrey, Holland, Samantha, Muldoon, Leslie, Neuwelt, Edward, Ambady, Prakash
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Preclinical Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651036/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.359
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