Enhancing the cytotoxicity of chemoradiation with radiation-guided delivery of anti-MGMT morpholino oligonucleotides in non-methylated solid tumors

The DNA repair enzyme O(6)-methylguanine DNA methyltransferase (MGMT) is epigenetically silenced in some tumors by MGMT gene promoter methylation. MGMT-hypermethylated solid tumors have enhanced susceptibility to the cytotoxic effects of alkylating chemotherapy such as temozolomide, compared with no...

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Detaylı Bibliyografya
Yayımlandı:Cancer Gene Ther
Asıl Yazarlar: Ambady, P, Wu, Y J, Walker, J M, Kersch, C, Pagel, M A, Woltjer, R L, Fu, R, Muldoon, L L, Neuwelt, E A
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2017
Konular:
Original Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5605678/
https://ncbi.nlm.nih.gov/pubmed/28752860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cgt.2017.27
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