EPCO-05. LOSS OF THE H4 LYSINE METHYLTRANSFERASE KMT5B DRIVES INVASION / MIGRATION BY DEPLETING H3K27me3 AT LOCI OTHERWISE RETAINED IN H3K27M MUTANT DIPG CELLS

Diffuse intrinsic pontine glioma (DIPG) and other diffuse midline glioma (DMG) are characterised by K27M mutations in histone H3 variants. The major functional consequence is a global loss of the repressive mark H3K27me3, causing a raft of transcriptional changes promoting tumorigenesis, although ce...

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Détails bibliographiques
Publié dans:Neuro Oncol
Auteurs principaux: Kessler, Ketty, Mackay, Alan, Molinari, Valeria, Tari, Haider, Burford, Anna, Sottoriva, Andrea, Vinci, Maria, Jones, Chris
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2020
Sujets:
(Epi)Genetics and Computational Omics
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651029/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.284
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