RTID-08. A PHASE 1/2 STUDY OF SELINEXOR IN COMBINATION WITH STANDARD OF CARE THERAPY FOR NEWLY DIAGNOSED OR RECURRENT GLIOBLASTOMA (ndGBM OR rGBM)

BACKGROUND: GBM is the most common and most aggressive primary brain tumor with poor prognosis and median overall survival (mOS) of patients with ndGBM and rGBM being 15 vs 5-7 months, respectively. Selinexor is a first-in class, oral, selective nuclear export inhibitor which forces nuclear retentio...

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Bibliographic Details
Published in:Neuro Oncol
Main Authors: Wen, Patrick, Odia, Yazmin, Mehta, Minesh, Goldlust, Samuel, Tamir, Sharon, Shacham, Sharon, Wang, Hongwei, Sheehan, Heidi, Li, Kai
Format: Artigo
Language:Inglês
Published: Oxford University Press 2020
Subjects:
Randomized Trials in Development
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651017/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.813
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