RTID-12. PHASE 2 TRIAL OF TUMOR TREATING FIELDS (TTFIELDS) PLUS RADIATION THERAPY (RT) PLUS TEMOZOLAMIDE (TMZ) COMPARED TO RT PLUS TEMOZOLOMIDE IN NEWLY DIAGNOSED GLIOBLASTOMA (ndGBM)

OBJECTIVE: In the EF-14 phase 3 trial, TTFields 9200 kHz) added to maintenance TMZ increased median OS to 20.9 months versus 16.0 months with maintenance TMZ (p< 0.001) in ndGBM. Preclinical investigations showed that TTFields/RT have a synergistic effect. A pilot study (N=10) in ndGBM demonstrat...

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Bibliografiske detaljer
Udgivet i:Neuro Oncol
Main Authors: Grossman, Rachel, Limon, Dror, Bokstein, Felix, Harosh, Carmit Ben, Blumenthal, Deborah, Ram, Zvi
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2020
Fag:
Randomized Trials in Development
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651443/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.817
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