DDRE-16. SYNERGISTIC TUMOR SUPPRESSION FROM COMBINATION OF ONC201 AND EPIGENETIC MODULATORS EZH2 OR HDAC INHIBITOR PROVIDES A NOVEL TREATMENT STRATEGY FOR GBM AND DMG

ONC201 is a promising anti-cancer agent that kills tumor cells by triggering an integrated stress response (ISR) dependent on ATF4. ONC201 demonstrated tumor regression and prolonged disease stability in patients with histone H3K27M-mutated midline glioma. The Enhancer of Zeste Homolog 2 (EZH2), a s...

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Bibliografiske detaljer
Udgivet i:Neuro Oncol
Main Authors: Zhang, Yiqun, Zhou, Lanlan, Howard, Safran, Seyhan, Attila, El-Deiry, Wafik
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2020
Fag:
Drug Discovery, Drug Resistance
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7650938/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.261
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