VRK1 Phosphorylates Tip60/KAT5 and Is Required for H4K16 Acetylation in Response to DNA Damage

SIMPLE SUMMARY: Dynamic remodeling of chromatin requires epigenetic modifications of histones. DNA damage induced by doxorubicin causes an increase in histone H4K16ac, a marker of local chromatin relaxation. We studied the role that VRK1, a chromatin kinase activated by DNA damage, plays in this ear...

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Publicado en:Cancers (Basel)
Main Authors: García-González, Raúl, Morejón-García, Patricia, Campillo-Marcos, Ignacio, Salzano, Marcella, Lazo, Pedro A.
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7650776/
https://ncbi.nlm.nih.gov/pubmed/33076429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12102986
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