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Stress Granule Assembly Can Facilitate but Is Not Required for TDP-43 Cytoplasmic Aggregation

Stress granules (SGs) are hypothesized to facilitate TAR DNA-binding protein 43 (TDP-43) cytoplasmic mislocalization and aggregation, which may underly amyotrophic lateral sclerosis pathology. However, much data for this hypothesis is indirect. Additionally, whether P-bodies (PBs; related mRNA-prote...

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Bibliografiske detaljer
Udgivet i:Biomolecules
Main Authors: Fernandes, Nikita, Nero, Luke, Lyons, Shawn M., Ivanov, Pavel, Mittelmeier, Telsa M., Bolger, Timothy A., Buchan, J. Ross
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7650667/
https://ncbi.nlm.nih.gov/pubmed/32992901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom10101367
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