Engineering and Preclinical Evaluation of Western Reserve Oncolytic Vaccinia Virus Expressing A167Y Mutant Herpes Simplex Virus Thymidine Kinase

Viral replication of thymidine kinase deleted (tk(−)) vaccinia virus (VV) is attenuated in resting normal cells, enabling cancer selectivity, however, replication potency of VV-tk(−) appears to be diminished in cancer cells. Previously, we found that wild-type herpes simplex virus (HSV)-tk (HSV-tk)...

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Pubblicato in:Biomedicines
Autori principali: Islam, S. M. Bakhtiar UL, Hong, Young Mi, Ornella, Mefotse saha Cyrelle, Ngabire, Daniel, Jang, Hyunjung, Cho, Euna, Kim, Eung-Kyun, Hale, Jessye Jin Joo, Kim, Cy Hyun, Ahn, Soon Cheol, Cho, Mong, Hwang, Tae-Ho
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7650665/
https://ncbi.nlm.nih.gov/pubmed/33081279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biomedicines8100426
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