CBIO-21. H3F3A G34R/V MUTATIONS INDUCE CHROMOSOMAL INSTABILITY AND PROMOTE PEDIATRIC HIGH-GRADE GLIOMA FORMATION

Histone H3.3 G34R/V mutations are drivers of pediatric high-grade glioma (pHGG). However, the mechanism(s) responsible for G34R/V induced tumorigenesis are unclear. We observed that pHGG cells with H3.3 G34 mutations have significantly reduced phosphorylation at H3.3 S31 as compared to H3.3 WT cell...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Neuro Oncol
Autores principales: Day, Charles, Grigore, Florina, Langfald, Alyssa, Robinson, James, Hinchcliffe, Edward
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2020
Materias:
Cell Biology (Cell Cycle Regulation, DNA Repair/Modulation)
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7650451/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.081
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares