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GENE-15. HISTONE H3.3 MUTATIONS DRIVE TUMORIGENESIS THROUGH CHROMOSOMAL INSTABILITY
BACKGROUND: Heterozygous mutations in Histone H3.3 (K27M, G34R/V) occur in 70–80% of pediatric high-grade gliomas and 78% of diffuse intrinsic pontine gliomas (DIPG). These mutations are also found in low-grade gliomas that progress to higher grade tumors. Epigenetic dysregulation resulting from alt...
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| Publicado no: | Neuro Oncol |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6477263/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.086 |
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