DIPG-05. HISTONE H3.3 K27M IMPAIRS SER31 PHOSPHORYLATION, RESULTING IN CHROMOSOMAL INSTABILITY, LOSS OF CELL CYCLE CHECKPOINT CONTROL, AND TUMOR FORMATION

Diffuse midline gliomas with the H3.3 K27M mutation are lethal brain tumors in children. H3 K27M causes global loss of Lys27 triple methylation (Lys27me3), inducing epigenetic reprograming. Here we show that H3.3 K27M also causes decreased H3.3 Ser31 phosphorylation on mitotic chromosomes. We show t...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Day, Charles, Langfald, Alyssa, Grigore, Florina, Fadness, Sela, Sepaniac, Leslie, Stumpff, Jason, Vaughan, Kevin, Robinson, James, Hinchcliffe, Edward
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Diffuse Midline Glioma/DIPG
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715219/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.057
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