DIPG-05. HISTONE H3.3 K27M IMPAIRS SER31 PHOSPHORYLATION, RESULTING IN CHROMOSOMAL INSTABILITY, LOSS OF CELL CYCLE CHECKPOINT CONTROL, AND TUMOR FORMATION

Diffuse midline gliomas with the H3.3 K27M mutation are lethal brain tumors in children. H3 K27M causes global loss of Lys27 triple methylation (Lys27me3), inducing epigenetic reprograming. Here we show that H3.3 K27M also causes decreased H3.3 Ser31 phosphorylation on mitotic chromosomes. We show t...

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Détails bibliographiques
Publié dans:Neuro Oncol
Auteurs principaux: Day, Charles, Langfald, Alyssa, Grigore, Florina, Fadness, Sela, Sepaniac, Leslie, Stumpff, Jason, Vaughan, Kevin, Robinson, James, Hinchcliffe, Edward
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2020
Sujets:
Diffuse Midline Glioma/DIPG
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715219/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.057
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