DIPG-05. HISTONE H3.3 K27M IMPAIRS SER31 PHOSPHORYLATION, RESULTING IN CHROMOSOMAL INSTABILITY, LOSS OF CELL CYCLE CHECKPOINT CONTROL, AND TUMOR FORMATION

Diffuse midline gliomas with the H3.3 K27M mutation are lethal brain tumors in children. H3 K27M causes global loss of Lys27 triple methylation (Lys27me3), inducing epigenetic reprograming. Here we show that H3.3 K27M also causes decreased H3.3 Ser31 phosphorylation on mitotic chromosomes. We show t...

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Dettagli Bibliografici
Pubblicato in:Neuro Oncol
Autori principali: Day, Charles, Langfald, Alyssa, Grigore, Florina, Fadness, Sela, Sepaniac, Leslie, Stumpff, Jason, Vaughan, Kevin, Robinson, James, Hinchcliffe, Edward
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2020
Soggetti:
Diffuse Midline Glioma/DIPG
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715219/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.057
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