PDTM-38. HISTONE H3.3 SER31 PHOSPHORYLATION REGULATES CHROMOSOME SEGREGATION AND CELL CYCLE CHECKPOINT CONTROL AND IS IMPAIRED IN PEDIATRIC GLIOMAS

Diffuse intrinsic pontine glioma (DIPG) carries a signature mutation in histone H3.3 (K27M) that induces epigenetic reprogramming via suppressed Lys27 triple methylation (K27me3). H3.3 has a Ser at position 31, which is adjacent to the K27M DIPG mutation. H3.3 Ser31 is phosphorylated beginning in pr...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Day, Charles, Langfald, Alyssa, Fadness, Sela, Zykova, Tatyana, Sepaniac, Leslie, Stumpff, Jason, Dong, Zigang, Vaughan, Kevin, Robinson, James, Hinchcliffe, Edward
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Pediatric Tumors
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847117/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.814
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