GENE-15. HISTONE H3.3 MUTATIONS DRIVE TUMORIGENESIS THROUGH CHROMOSOMAL INSTABILITY

BACKGROUND: Heterozygous mutations in Histone H3.3 (K27M, G34R/V) occur in 70–80% of pediatric high-grade gliomas and 78% of diffuse intrinsic pontine gliomas (DIPG). These mutations are also found in low-grade gliomas that progress to higher grade tumors. Epigenetic dysregulation resulting from alt...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Neuro Oncol
Päätekijät: Grigore, Florina-Nicoleta, Day, Charles, Yang, Hana, Hinchcliffe, Edward, Robinson, James
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 2019
Aiheet:
Genetics/Epigentics
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477263/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.086
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