TMOD-36. THE DEVELOPMENT OF A NOVEL MOUSE MODEL TO STUDY THE ROLE OF HISTONE MUTATIONS AND MODIFICATIONS IN PEDIATRIC HIGH-GRADE GLIOMA

Pediatric glioblastoma and diffuse intrinsic pontine glioma are high-grade gliomas of children (pHGG) with a median overall survival of under 15 months and among the most lethal cancers. Mutations in histone H3.3 and H3.1 occur as an early event in pHGG. H3.3G34R/V-mutations occur in pHGG of cerebra...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Grigore, Florina, Day, Charles, Hanson, Nicholas, Langfald, Alyssa, Sarkaria, Jann, Daniels, David, Hinchcliffe, Edward, Robinson, James
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Tumor Models
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651583/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.986
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