CBIO-16. SUPPRESSION OF HISTONE H3.3 MITOTIC PHOSPHORYLATION DRIVES DEVELOPMENT OF H3K27M-MUTANT DIFFUSE MIDLINE GLIOMAS

Pediatric midline gliomas – including DIPG – are lethal brain tumors in children, with poor prognosis and limited treatment options that provide only short-term benefits. The majority have a lysine-to-methionine substitution at residue 27 (H3K27M) in genes expressing histone H3 – predominantly in th...

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Detalles Bibliográficos
Publicado en:Neuro Oncol
Main Authors: Day, Charles, Langfald, Alyssa, Grigore, Florina, Sepaniac, Leslie, Stumpff, Jason, Vaughan, Kevin, Robinson, James, Hinchcliffe, Edward
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2020
Assuntos:
Cell Biology (Cell Cycle Regulation, DNA Repair/Modulation)
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7650404/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.076
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