The nuclear pore primes recombination-dependent DNA synthesis at arrested forks by promoting SUMO removal

Nuclear Pore complexes (NPCs) act as docking sites to anchor particular DNA lesions facilitating DNA repair by elusive mechanisms. Using replication fork barriers in fission yeast, we report that relocation of arrested forks to NPCs occurred after Rad51 loading and its enzymatic activity. The E3 SUM...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Kramarz, Karol, Schirmeisen, Kamila, Boucherit, Virginie, Ait Saada, Anissia, Lovo, Claire, Palancade, Benoit, Freudenreich, Catherine, Lambert, Sarah A. E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7648084/
https://ncbi.nlm.nih.gov/pubmed/33159083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-19516-z
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