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Identification of a signalling mechanism by which the microbiome regulates Th17 cell-mediated depressive-like behaviors in mice

Microbiota dysbiosis has been linked to major depressive disorder, but the mechanisms whereby the microbiota modulates mood remain poorly understood. We show that Segmented filamentous bacteria (SFB)-deficient mice are resilient to the induction of depressive-like behavior, and are re-sensitized whe...

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Detalhes bibliográficos
Publicado no:Am J Psychiatry
Main Authors: Medina-Rodriguez, Eva M., Madorma, Derik, O’Connor, Gregory, Mason, Brittany L., Han, Dongmei, Deo, Sapna, Oppenheimer, Mark, Nemeroff, Charles B., Trivedi, Madhukar H., Daunert, Sylvia, Beurel, Eléonore
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7647050/
https://ncbi.nlm.nih.gov/pubmed/32731813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1176/appi.ajp.2020.19090960
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