Identification of a signalling mechanism by which the microbiome regulates Th17 cell-mediated depressive-like behaviors in mice

Microbiota dysbiosis has been linked to major depressive disorder, but the mechanisms whereby the microbiota modulates mood remain poorly understood. We show that Segmented filamentous bacteria (SFB)-deficient mice are resilient to the induction of depressive-like behavior, and are re-sensitized whe...

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Bibliographic Details
Published in:Am J Psychiatry
Main Authors: Medina-Rodriguez, Eva M., Madorma, Derik, O’Connor, Gregory, Mason, Brittany L., Han, Dongmei, Deo, Sapna, Oppenheimer, Mark, Nemeroff, Charles B., Trivedi, Madhukar H., Daunert, Sylvia, Beurel, Eléonore
Format: Artigo
Language:Inglês
Published: 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7647050/
https://ncbi.nlm.nih.gov/pubmed/32731813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1176/appi.ajp.2020.19090960
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