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PAR4 activation involves extracellular loop 3 and transmembrane residue Thr153
Protease-activated receptor 4 (PAR4) mediates sustained thrombin signaling in platelets and is required for a stable thrombus. PAR4 is activated by proteolysis of the N terminus to expose a tethered ligand. The structural basis for PAR4 activation and the location of its ligand binding site (LBS) ar...
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| Udgivet i: | Blood |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society of Hematology
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7645988/ https://ncbi.nlm.nih.gov/pubmed/32575122 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019004634 |
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