INVOLVEMENT OF THE SECOND EXTRACELLULAR LOOP AND TRANSMEMBRANE RESIDUES OF CCR5 IN INHIBITOR BINDING AND HIV-1 FUSION: INSIGHTS TO MECHANISM OF ALLOSTERIC INHIBITION

The C-C chemokine receptor 5 (CCR5), a member of G-protein-coupled receptors, serves as a co-receptor for human immunodeficiency virus type 1 (HIV-1). In the present study, we examined the interactions between CCR5 and novel CCR5 inhibitors containing the spirodiketopiperazine (SDP) scaffold, AK530...

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Main Authors: Maeda, Kenji, Das, Debananda, Yin, Philip D., Tsuchiya, Kiyoto, Ogata-Aoki, Hiromi, Nakata, Hirotomo, Norman, Rachael, Hackney, Lauren, Takaoka, Yoshikazu, Mitsuya, Hiroaki
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2008
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2630503/
https://ncbi.nlm.nih.gov/pubmed/18590744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.06.041
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