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The mechanistic role of alpha-synuclein in the nucleus: impaired nuclear function caused by familial Parkinson’s disease SNCA mutations

Alpha-synuclein SNCA has been implicated in the etiology of Parkinson’s disease (PD); however, the normal function of alpha-synuclein protein and the pathway that mediates its pathogenic effect is yet to be discovered. We investigated the mechanistic role of SNCA in the nucleus utilizing isogenic hu...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Hum Mol Genet
Hauptverfasser: Chen, Vivian, Moncalvo, Malik, Tringali, Dominic, Tagliafierro, Lidia, Shriskanda, Ahila, Ilich, Ekaterina, Dong, Wendy, Kantor, Boris, Chiba-Falek, Ornit
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2020
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7645704/
https://ncbi.nlm.nih.gov/pubmed/32954426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddaa183
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