Downregulation of SNCA Expression by Targeted Editing of DNA Methylation: A Potential Strategy for Precision Therapy in PD

Elevated levels of SNCA have been implicated in the pathogenesis of Parkinson’s disease (PD), while normal physiological levels of SNCA are needed to maintain neuronal function. We ought to develop new therapeutic strategies targeting the regulation of SNCA expression. DNA methylation at SNCA intron...

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Bibliografske podrobnosti
izdano v:Mol Ther
Main Authors: Kantor, Boris, Tagliafierro, Lidia, Gu, Jeffrey, Zamora, Madison E., Ilich, Ekaterina, Grenier, Carole, Huang, Zhiqing Y., Murphy, Susan, Chiba-Falek, Ornit
Format: Artigo
Jezik:Inglês
Izdano: American Society of Gene & Cell Therapy 2018
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6224806/
https://ncbi.nlm.nih.gov/pubmed/30266652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2018.08.019
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