Downregulation of SNCA Expression by Targeted Editing of DNA Methylation: A Potential Strategy for Precision Therapy in PD

Elevated levels of SNCA have been implicated in the pathogenesis of Parkinson’s disease (PD), while normal physiological levels of SNCA are needed to maintain neuronal function. We ought to develop new therapeutic strategies targeting the regulation of SNCA expression. DNA methylation at SNCA intron...

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Foilsithe in:Mol Ther
Main Authors: Kantor, Boris, Tagliafierro, Lidia, Gu, Jeffrey, Zamora, Madison E., Ilich, Ekaterina, Grenier, Carole, Huang, Zhiqing Y., Murphy, Susan, Chiba-Falek, Ornit
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society of Gene & Cell Therapy 2018
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Original Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6224806/
https://ncbi.nlm.nih.gov/pubmed/30266652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2018.08.019
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