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The mechanistic role of alpha-synuclein in the nucleus: impaired nuclear function caused by familial Parkinson’s disease SNCA mutations

Alpha-synuclein SNCA has been implicated in the etiology of Parkinson’s disease (PD); however, the normal function of alpha-synuclein protein and the pathway that mediates its pathogenic effect is yet to be discovered. We investigated the mechanistic role of SNCA in the nucleus utilizing isogenic hu...

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Detalhes bibliográficos
Publicado no:Hum Mol Genet
Main Authors: Chen, Vivian, Moncalvo, Malik, Tringali, Dominic, Tagliafierro, Lidia, Shriskanda, Ahila, Ilich, Ekaterina, Dong, Wendy, Kantor, Boris, Chiba-Falek, Ornit
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7645704/
https://ncbi.nlm.nih.gov/pubmed/32954426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddaa183
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