FAK activity in cancer‐associated fibroblasts is a prognostic marker and a druggable key metastatic player in pancreatic cancer

Cancer‐associated fibroblasts (CAFs) are considered the most abundant type of stromal cells in pancreatic ductal adenocarcinoma (PDAC), playing a critical role in tumour progression and chemoresistance; however, a druggable target on CAFs has not yet been identified. Here we report that focal adhesi...

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Publié dans:EMBO Mol Med
Auteurs principaux: Zaghdoudi, Sonia, Decaup, Emilie, Belhabib, Ismahane, Samain, Rémi, Cassant‐Sourdy, Stéphanie, Rochotte, Julia, Brunel, Alexia, Schlaepfer, David, Cros, Jérome, Neuzillet, Cindy, Strehaiano, Manon, Alard, Amandine, Tomasini, Richard, Rajeeve, Vinothini, Perraud, Aurélie, Mathonnet, Muriel, Pearce, Oliver MT, Martineau, Yvan, Pyronnet, Stéphane, Bousquet, Corinne, Jean, Christine
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2020
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7645544/
https://ncbi.nlm.nih.gov/pubmed/33025708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.202012010
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