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Optimality criteria for futility stopping boundaries for group sequential designs with a continuous endpoint
BACKGROUND: In clinical trials with fixed study designs, statistical inference is only made when the trial is completed. In contrast, group sequential designs allow an early stopping of the trial at interim, either for efficacy when the treatment effect is significant or for futility when the treatm...
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| Veröffentlicht in: | BMC Med Res Methodol |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
BioMed Central
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7643306/ https://ncbi.nlm.nih.gov/pubmed/33153438 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12874-020-01141-5 |
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