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Optimality criteria for futility stopping boundaries for group sequential designs with a continuous endpoint

BACKGROUND: In clinical trials with fixed study designs, statistical inference is only made when the trial is completed. In contrast, group sequential designs allow an early stopping of the trial at interim, either for efficacy when the treatment effect is significant or for futility when the treatm...

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Detalhes bibliográficos
Publicado no:BMC Med Res Methodol
Main Authors: Li, Xieran, Herrmann, Carolin, Rauch, Geraldine
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7643306/
https://ncbi.nlm.nih.gov/pubmed/33153438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12874-020-01141-5
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