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Optimality criteria for futility stopping boundaries for group sequential designs with a continuous endpoint
BACKGROUND: In clinical trials with fixed study designs, statistical inference is only made when the trial is completed. In contrast, group sequential designs allow an early stopping of the trial at interim, either for efficacy when the treatment effect is significant or for futility when the treatm...
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| 出版年: | BMC Med Res Methodol |
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| 主要な著者: | , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
BioMed Central
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7643306/ https://ncbi.nlm.nih.gov/pubmed/33153438 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12874-020-01141-5 |
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