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Optimality criteria for futility stopping boundaries for group sequential designs with a continuous endpoint
BACKGROUND: In clinical trials with fixed study designs, statistical inference is only made when the trial is completed. In contrast, group sequential designs allow an early stopping of the trial at interim, either for efficacy when the treatment effect is significant or for futility when the treatm...
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| Wydane w: | BMC Med Res Methodol |
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| Główni autorzy: | , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
BioMed Central
2020
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7643306/ https://ncbi.nlm.nih.gov/pubmed/33153438 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12874-020-01141-5 |
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