Conformation-selective tau monoclonal antibodies inhibit tau pathology in primary neurons and a mouse model of Alzheimer’s disease

BACKGROUND: The spread of tau pathology in Alzheimer’s disease (AD) is mediated by cell-to-cell transmission of pathological tau seeds released from neurons that, upon internalization by recipient neurons, template the misfolding of naïve cellular tau, thereby propagating fibrillization. We hypothes...

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Detalhes bibliográficos
Publicado no:Mol Neurodegener
Main Authors: Gibbons, Garrett S., Kim, Soo-Jung, Wu, Qihui, Riddle, Dawn M., Leight, Susan N., Changolkar, Lakshmi, Xu, Hong, Meymand, Emily S., O’Reilly, Mia, Zhang, Bin, Brunden, Kurt R., Trojanowski, John Q., Lee, Virginia M. Y.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7643305/
https://ncbi.nlm.nih.gov/pubmed/33148293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-020-00404-5
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