Detection of Alzheimer’s disease (AD) specific tau pathology with conformation-selective anti-tau monoclonal antibody in co-morbid frontotemporal lobar degeneration-tau (FTLD-tau)

Pathological tau aggregates in Alzheimer’s disease (AD) and frontotemporal lobar degeneration-tau (FTLD-tau) adopt distinct conformations differentiated by the AD-tau specific monoclonal antibody (mAb) GT-38 that are not readily visualized using phosphorylation-specific anti-tau mAbs. To determine t...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol Commun
Main Authors: Gibbons, Garrett S., Kim, Soo-Jung, Robinson, John L., Changolkar, Lakshmi, Irwin, David J., Shaw, Leslie M., Lee, Virginia M.-Y., Trojanowski, John Q.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6399892/
https://ncbi.nlm.nih.gov/pubmed/30832741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-019-0687-5
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