Detection of Alzheimer’s disease (AD) specific tau pathology with conformation-selective anti-tau monoclonal antibody in co-morbid frontotemporal lobar degeneration-tau (FTLD-tau)

Pathological tau aggregates in Alzheimer’s disease (AD) and frontotemporal lobar degeneration-tau (FTLD-tau) adopt distinct conformations differentiated by the AD-tau specific monoclonal antibody (mAb) GT-38 that are not readily visualized using phosphorylation-specific anti-tau mAbs. To determine t...

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Udgivet i:Acta Neuropathol Commun
Main Authors: Gibbons, Garrett S., Kim, Soo-Jung, Robinson, John L., Changolkar, Lakshmi, Irwin, David J., Shaw, Leslie M., Lee, Virginia M.-Y., Trojanowski, John Q.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2019
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6399892/
https://ncbi.nlm.nih.gov/pubmed/30832741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-019-0687-5
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