Poly(ADP-ribose) glycohydrolase inhibition sequesters NAD+ to potentiate the metabolic lethality of alkylating chemotherapy in IDH mutant tumor cells

Nicotinamide adenine dinucleotide (NAD+) is an essential cofactor metabolite and is the currency of metabolic transactions critical for cell survival. Depending on tissue context and genotype, cancer cells have unique dependencies on NAD+ metabolic pathways. Poly(ADP-ribose) polymerases (PARPs) cata...

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Vydáno v:Cancer Discov
Hlavní autoři: Nagashima, Hiroaki, Lee, Christine K., Tateishi, Kensuke, Higuchi, Fumi, Subramanian, Megha, Rafferty, Seamus, Melamed, Lisa, Miller, Julie J., Wakimoto, Hiroaki, Cahill, Daniel P.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7642007/
https://ncbi.nlm.nih.gov/pubmed/32606138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-20-0226
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