Strict conformational demands of RNA cleavage in bulge-loops created by peptidyl-oligonucleotide conjugates

Potent knockdown of pathogenic RNA in vivo is an urgent health need unmet by both small-molecule and biologic drugs. ‘Smart’ supramolecular assembly of catalysts offers precise recognition and potent destruction of targeted RNA, hitherto not found in nature. Peptidyl-oligonucleotide ribonucleases ar...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Staroseletz, Yaroslav, Amirloo, Bahareh, Williams, Aled, Lomzov, Alexander, Burusco, Kepa K, Clarke, David J, Brown, Tom, Zenkova, Marina A, Bichenkova, Elena V
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Chemical Biology and Nucleic Acid Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7641753/
https://ncbi.nlm.nih.gov/pubmed/33010175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa780
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados