Strict conformational demands of RNA cleavage in bulge-loops created by peptidyl-oligonucleotide conjugates

Potent knockdown of pathogenic RNA in vivo is an urgent health need unmet by both small-molecule and biologic drugs. ‘Smart’ supramolecular assembly of catalysts offers precise recognition and potent destruction of targeted RNA, hitherto not found in nature. Peptidyl-oligonucleotide ribonucleases ar...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Staroseletz, Yaroslav, Amirloo, Bahareh, Williams, Aled, Lomzov, Alexander, Burusco, Kepa K, Clarke, David J, Brown, Tom, Zenkova, Marina A, Bichenkova, Elena V
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Chemical Biology and Nucleic Acid Chemistry
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7641753/
https://ncbi.nlm.nih.gov/pubmed/33010175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa780
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