ERH facilitates microRNA maturation through the interaction with the N-terminus of DGCR8

The microprocessor complex cleaves the primary transcript of microRNA (pri-miRNA) to initiate miRNA maturation. Microprocessor is known to consist of RNase III DROSHA and dsRNA-binding DGCR8. Here, we identify Enhancer of Rudimentary Homolog (ERH) as a new component of Microprocessor. Through a crys...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Kwon, S Chul, Jang, Harim, Shen, Siyuan, Baek, S Chan, Kim, Kijun, Yang, Jihye, Kim, Jeesoo, Kim, Jong-Seo, Wang, Suman, Shi, Yunyu, Li, Fudong, Kim, V Narry
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
RNA and RNA-protein complexes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7641749/
https://ncbi.nlm.nih.gov/pubmed/33035348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa827
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