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Genomic clustering facilitates nuclear processing of suboptimal pri-miRNA loci
Nuclear processing of most miRNAs is mediated by Microprocessor, comprised of RNase III enzyme Drosha and its cofactor DGCR8. Here, we uncover a hidden layer of Microprocessor regulation via studies of Dicer-independent mir-451, which is clustered with canonical mir-144. Although mir-451 is fully de...
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| Publicado no: | Mol Cell |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7546447/ https://ncbi.nlm.nih.gov/pubmed/32302542 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.02.009 |
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