DGCR8-dependent efficient pri-miRNA processing of human pri-miR-9-2

Microprocessor complex, including DiGeorge syndrome critical region gene 8 (DGCR8) and DROSHA, recognizes and cleaves primary transcripts of microRNAs (pri-miRNAs) in the maturation of canonical miRNAs. The study of DGCR8 haploinsufficiency reveals that the efficiency of this activity varies for dif...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Nogami, Masahiro, Miyamoto, Kazumasa, Hayakawa-Yano, Yoshika, Nakanishi, Atsushi, Yano, Masato, Okano, Hideyuki
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7995608/
https://ncbi.nlm.nih.gov/pubmed/33581109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100409
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