MD Simulations of the dsRBP DGCR8 Reveal Correlated Motions that May Aid pri-miRNA Binding

Over the past decade, microRNAs (miRNAs) have been shown to affect gene regulation by basepairing with messenger RNA, and their misregulation has been directly linked with cancer. DGCR8, a protein that contains two dsRNA-binding domains (dsRBDs) in tandem, is vital for nuclear maturation of primary...

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Bibliographic Details
Main Authors: Wostenberg, Christopher, Noid, W.G., Showalter, Scott A.
Format: Artigo
Language:Inglês
Published: The Biophysical Society 2010
Subjects:
Protein
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2895372/
https://ncbi.nlm.nih.gov/pubmed/20655853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.04.010
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