ZFAT binds to centromeres to control noncoding RNA transcription through the KAT2B–H4K8ac–BRD4 axis

Centromeres are genomic regions essential for faithful chromosome segregation. Transcription of noncoding RNA (ncRNA) at centromeres is important for their formation and functions. Here, we report the molecular mechanism by which the transcriptional regulator ZFAT controls the centromeric ncRNA tran...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Ishikura, Shuhei, Nakabayashi, Kazuhiko, Nagai, Masayoshi, Tsunoda, Toshiyuki, Shirasawa, Senji
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Gene regulation, Chromatin and Epigenetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7641738/
https://ncbi.nlm.nih.gov/pubmed/32997115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa815
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