Mechanism of Paeoniflorin in the Treatment of Bile Duct Ligation-Induced Cholestatic Liver Injury Using Integrated Metabolomics and Network Pharmacology

Paeoniflorin (PF) is the main active component of Paeonia lactiflora Pall., which is used in the treatment of severe cholestatic hepatitis. However, its biological mechanism in regulating bile acid metabolism and cholestatic liver injury has not been fully revealed. Our study aimed to reveal the mec...

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Bibliographic Details
Published in:Front Pharmacol
Main Authors: Wei, Shizhang, Ma, Xiao, Niu, Ming, Wang, Ruilin, Yang, Tao, Wang, Dan, Wen, Jianxia, Li, Haotian, Zhao, Yanling
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7641625/
https://ncbi.nlm.nih.gov/pubmed/33192530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.586806
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