Mechanism of Paeoniflorin in the Treatment of Bile Duct Ligation-Induced Cholestatic Liver Injury Using Integrated Metabolomics and Network Pharmacology

Paeoniflorin (PF) is the main active component of Paeonia lactiflora Pall., which is used in the treatment of severe cholestatic hepatitis. However, its biological mechanism in regulating bile acid metabolism and cholestatic liver injury has not been fully revealed. Our study aimed to reveal the mec...

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Dades bibliogràfiques
Publicat a:Front Pharmacol
Autors principals: Wei, Shizhang, Ma, Xiao, Niu, Ming, Wang, Ruilin, Yang, Tao, Wang, Dan, Wen, Jianxia, Li, Haotian, Zhao, Yanling
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2020
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7641625/
https://ncbi.nlm.nih.gov/pubmed/33192530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.586806
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