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Mechanism of Paeoniflorin in the Treatment of Bile Duct Ligation-Induced Cholestatic Liver Injury Using Integrated Metabolomics and Network Pharmacology

Paeoniflorin (PF) is the main active component of Paeonia lactiflora Pall., which is used in the treatment of severe cholestatic hepatitis. However, its biological mechanism in regulating bile acid metabolism and cholestatic liver injury has not been fully revealed. Our study aimed to reveal the mec...

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Foilsithe in:Front Pharmacol
Main Authors: Wei, Shizhang, Ma, Xiao, Niu, Ming, Wang, Ruilin, Yang, Tao, Wang, Dan, Wen, Jianxia, Li, Haotian, Zhao, Yanling
Formáid: Artigo
Teanga:Inglês
Foilsithe: Frontiers Media S.A. 2020
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7641625/
https://ncbi.nlm.nih.gov/pubmed/33192530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.586806
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