An injectable microparticle formulation provides long-term inhibition of hypothalamic ERK1/2 activity and sympathetic excitation in rats with heart failure

Sympathetic excitation contributes to clinical deterioration in systolic heart failure (HF). Significant inhibition of hypothalamic paraventricular nucleus (PVN) ERK1/2 signaling and a subsequent reduction of plasma norepinephrine (NE) levels in HF rats were achieved two weeks after a single subcuta...

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Foilsithe in:Mol Pharm
Main Authors: Naguib, Youssef W., Yu, Yang, Wei, Shun-Guang, Morris, Angie, Givens, Brittany E., Mekkawy, Aml I., Weiss, Robert M., Felder, Robert B., Salem, Aliasger K.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2020
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7641013/
https://ncbi.nlm.nih.gov/pubmed/32786958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.0c00501
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