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An injectable microparticle formulation for the sustained release of the specific MEK inhibitor PD98059: in vitro evaluation and pharmacokinetics

PD98059 is a reversible MEK inhibitor that we are investigating as a potential treatment for neurochemical changes in the brain that drive neurohumoral excitation in heart failure. In preliminary studies in a rat model that closely resembles human heart failure, we found that PD98059 gains access to...

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Bibliografiske detaljer
Udgivet i:Drug Deliv Transl Res
Main Authors: Naguib, Youssef W., Givens, Brittany E., Ho, Giang, Yu, Yang, Wei, Shun-Guang, Weiss, Robert M., Felder, Robert B., Salem, Aliasger K.
Format: Artigo
Sprog:Inglês
Udgivet: 2021
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7647946/
https://ncbi.nlm.nih.gov/pubmed/32378175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13346-020-00758-9
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