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An injectable microparticle formulation for the sustained release of the specific MEK inhibitor PD98059: in vitro evaluation and pharmacokinetics
PD98059 is a reversible MEK inhibitor that we are investigating as a potential treatment for neurochemical changes in the brain that drive neurohumoral excitation in heart failure. In preliminary studies in a rat model that closely resembles human heart failure, we found that PD98059 gains access to...
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| Published in: | Drug Deliv Transl Res |
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| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2021
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7647946/ https://ncbi.nlm.nih.gov/pubmed/32378175 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13346-020-00758-9 |
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