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A general method to quantify ligand-driven oligomerization from fluorescence-based images

Here we introduce fluorescence intensity fluctuation spectrometry for determining the identity, abundance, and stability of protein oligomers. This approach was tested on monomers and oligomers of known sizes and was used to uncover the oligomeric states of the epidermal growth factor receptor and t...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Nat Methods
Asıl Yazarlar: Stoneman, Michael R., Biener, Gabriel, Ward, Richard J., Pediani, John D., Badu, Dammar, Eis, Annie, Popa, Ionel, Milligan, Graeme, Raicu, Valerică
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2019
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7617210/
https://ncbi.nlm.nih.gov/pubmed/31110281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41592-019-0408-9
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