Genome-wide RNAi Screen Identifies Cohesin Genes as Modifiers of Renewal and Differentiation in Human HSCs

To gain insights into the regulatory mechanisms of hematopoietic stem cells (HSCs), we employed a genome-wide RNAi screen in human cord-blood derived cells and identified candidate genes whose knockdown maintained the HSC phenotype during culture. A striking finding was the identification of members...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Galeev, Roman, Baudet, Aurélie, Kumar, Praveen, Nilsson, Alexandra Rundberg, Nilsson, Björn, Soneji, Shamit, Törngren, Therese, Borg, Åke, Kvist, Anders, Larsson, Jonas
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7616965/
https://ncbi.nlm.nih.gov/pubmed/26997282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.02.082
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